Autism, Yeast Candida Infections and Associated Illnesses

The letter to download is the last letter on this page ..the preceding letters are self explanatory ..they lead to the invite from government scientists at FERA to present my hypothesis

From: Paul Jaep
Sent: 03 March 2010 21:35
To: PS/Bryan Davies (Secretariat)

Subject: The link between autism and the demise of the honey bee

Dear Lord Davies,
I write to you following corresponding with Defra spokesman Christopher Hussey who passed replies to me from Defra scientists to my written concerns. Hilary Benn was my first contact he asked Christopher to answer my initial inquiry.

The subject of my correspondence is the worrying situation surrounding the demise of the honey bee, the so called honey bee colony collapse disorder [CCD].I am afraid I am not satisfied with the replies I received from Defra scientists . Their assessment of the situation is insufficient and does not recognise the root cause of the issue we face . I include exchanges where the official explanation to an almost global problem is in the UK is poor weather conditions coupled with poor husbandry are the likely cause. This is very unlikely; the odds of this scenario would be vanishingly small. My correspondence explains why.

It’s clear to me that our widespread misuse of antibiotics has disrupted a natural balance that has now placed us in a dangerous situation. I consider, given the frightening growth rate in western diseases, autism, and the honey bees demise in particular that we have approximately 15 years before widespread devastation. Disease burden will overwhelm resources and coupled with the 30% reduction in food production predicted with the disappearance of the honey bee [by 2018 in the UK] will lead to a collapse in our economy ... much to the delight of our enemies. . National security could very much be at risk.

I have teamed up with my good friend Gary Smith in this regard; Gary Smith is the author of two influential papers detailing hitherto unknown mechanisms that cancer and pathogens use in disease progression. Gary’s initial paper is Cancer, inflammation and the AT1 and AT2 receptors The second paper published in 2009 is 'Learning from cancer: The adaptive growth, wound and immune responses' Gene Ther Mol Biol Vol 13, 158-185, 2009. Gary is also a contributing author to Anti-Cancer Therapeutics, a recent publication [2009] from Wiley. Links can be found in the Reference section of my site.

Gary spent last week at the GRC Angiotensin conference in Los Angeles, I include his poster presentation that he was asked to produce “on the hoof” while at the conference. Some very exciting progress was evident at the conference not least of which is the prospect of treating Alzheimer’s disease and other chronic inflammatory diseases with angiotensin receptor blockers .Something predicted by Gary back in 2004…. Scroll down the poster presentation to fig 9 for an insight of how pathogens and cancer disrupt our immune systems through injury responses.

Not all my research is in my site, I do believe I may have some answers to this very worrying situation. Gary and I would like to meet with you together with any other interested parties to discus add detail to the information I have provided.Regards

I look forward to your reply
Regards
Paul Jaep

Selected previous correspondence.

Dear Mr Jaep

Thank you for your email of 12 January to Hilary Benn about bees. I have been asked to reply.

Over the last two years Britain’s bee colonies have suffered significant losses probably due to a combination of factors including the poor spring/summer weather, the varroa mite, and other husbandry issues. Reports of honeybee colony losses are being investigated by Defra as a high priority. Defra announced on 21 January that there would be an extra £4.3 million to safeguard and undertake more research into the health of bees. Of this additional funding, nearly £2.3 million over the next two years will be allocated to the National Bee Unit to implement the first stage of the Department’s ‘Healthy Bees’ plan which was launched on 9 March. An additional £400,000 per annum will be allocated to the research and development programme for the next five years (currently around £200,000 per annum) of which £500,000 per annum will be channelled into a research programme into honeybees and other pollinators.

In addition to this, on 21 April Hilary Benn announced an initiative that would provide money for research into the decline of bees and other pollinators in the UK. Up to £10 million is to be invested to help to identify the main threats to bees and other insect pollinators. The funding will be made available to research teams across the UK under the Living With Environmental Change (LWEC) partnership, the major initiative by UK funders to help the UK respond effectively to changes to our environment. This is a joint initiative from the Biotechnology and Biological Sciences Research Council (BBSRC), Defra, the Natural Environment Research Council (NERC), the Wellcome Trust and the Scottish Executive.

The Chemicals Regulation Directorate (CRD is an Agency of the Health and Safety Executive) will continue to be involved with the development of bee risk assessment methodology, particularly through the revision of the European Plant Protection Office risk assessment scheme and guidelines that were also discussed at the International Commission for Plant-Bee Relationships (ICPBR). CRD would of course act on any substantive evidence should incidents occur in the UK and we will also continue to keep abreast of research and developments in other EU Member States and elsewhere to see if they are relevant to the UK.

Over the last year, the National Bee Unit (https://secure.fera.defra.gov.uk/beebase/) has been investigating the causes of cases of significant colony losses. Analysis of the results of this research shows that the most important risk factor in the mortality or weakening of colonies is deformed wing virus, a virus transmitted by the parasitic varroa mite, clearly indicating failed or unsuccessful treatments of mite infestations. This highlights the importance of improving standards of husbandry and is in agreement with results from earlier studies investigating abnormal colony losses in 2007. The impact of mite infestations was exacerbated by the unfavourable weather conditions over the last two years which did not allow colonies to prosper. A final report with the results from the investigations into abnormal colony losses will be published later this year.

Yours sincerely

Christopher Hussey
Defra – Customer Contact Unit
Department for Environment, Food and Rural Affairs (Defra)

Christopher , thank you for your reply , I am aware of the efforts been made to understand this environmental catastrophe, as currently without intervention in both the CCD and autism we are facing the decline of our civilisation, I believe the two conditions are linked and I believe I can prove it ...To be brutally honest looking at improved husbandry is obviously not the answer and it shows a lack of understanding in the problem .The fact is this phenomena is happening across the developed world, there must be a common denominator . Australia notably, intriguingly is the exception ..Now what is Australia doing or not doing that keeps their bees healthy . Well it looks like Australia’s policy on prohibiting the use of antibiotics for animal welfare is the key .. I do provide the necessary studies to back my hypotheses up .. So please look at the detailed information i provide in my web site below and give me your comments, the situation is too serious not to give it your full attention .
I look forward to your reply
http://www.yeast-candida-infections-uk.co.uk/antibiotic_impact_on_animals
Regards

Paul Jaep

Dear Mr Jaep

Thank you for your further email of 29 January about bees.

We have noted your comments. As regards Australia, you may wish to note that varroa is not present in the country which will contribute to its high bee health status.

Yours sincerely

This letter prompted the invite to present my data at FERA research establishment Yorkshire on the 12 July 2010

Christopher Hussey
Defra – Customer Contact Unit
Department for Environment, Food and Rural Affairs (Defra)

Mr Hussey , thank you for your reply,

I was aware that the varroa mite is not a problem in Australia, but outside Australia including the US in the last few years another bee mite " Nosema ceranae " is also being found in increasing numbers. It’s no coincidence . it’s a classic example of a opportunist infection/parasite taking advantage of compromised immunity…
From my site .

"The bee population along with many other insects have suffered a catastrophic decline in numbers in recent years; downgraded immunity is widely believed to be the major factor. Researchers have dissected bees that have died and they have found that their immune systems have "totally gone to pieces". "It is like they just lost their immune system and anything will kill them".
The few bees left inside the hive were carrying "a tremendous number of pathogens" - virtually every known bee virus could be detected in the insects, she said, and some bees were carrying five or six viruses at a time, as well as fungal infections. Because of this it was assumed that the bees' immune systems were being suppressed in some way. - The Independent “

My point is that this is paralleled in autistic children they have been found to host many infectious agents including true parasites. Lyme disease is curiously being diagnosed in autistic toddlers, as you’re probably aware this is thought to be contracted via a tick, Lyme disease is increasing simultaneously across the developed world there are not too many explanations for this.. Reduced immunity certainly plays a part

.

As an explanation for CCD poor spring/summer weather and husbandry issues really does not cut it. The problem is world wide with the exception of Australia; bees are affected in all climes and conditions. Australia is subject to climate change and has varied changing climes yet bees there remain healthy… so poor weather or climate change would not be a factor , poor husbandry is also grabbing at straws. Has Australia maintained higher standards of husbandry while in the rest of the world the standard of husbandry simultaneously has declined! Its a nonsense..

As per my previous reply i have the evidence , Antibiotics in all probability have caused and are still causing an environmental disaster .It wouldn’t take much to test my hypothesis . Look at it like this . Failure to find a cause in either autism or the colony collapse disorder will bring our civilisation to an end ..Can you afford to ignore a possible answer to both Once again I look forward to your reply.
Regards
Paul Jaep

Ps

I have teamed up with my good friend Gary Smith in this regard Gary Smith is the author of two influential papers detailing hitherto unknown mechanisms that cancer and pathogens use in disease progression. Gary’s initial paper is Cancer, inflammation and the AT1 and AT2 receptors The second paper published in 2009 is 'Learning from cancer: The adaptive growth, wound and immune responses' Gene Ther Mol Biol Vol 13, 158-185, 2009. Gary is also a contributing author to Anti-Cancer Therapeutics, a recent publication [2009] from Wiley. Links can be found in the Reference section of my site.

Not all my research is in my site, I do believe I may have some answers to this very worrying situation. Gary and I would be more than willing to meet with you or other interested parties to discus add detail to the information I have provided.

A search on pubmed 'nosema ceranae honey bee' yields:
PMID: 19909977 PMID: 19467238 PMID: 19457054 PMID: 18647336 PMID: 18441873 PMID: 17880997

Department for Environment, Food and Rural Affairs (Defra)

Your address

Dear Mr/Mrs. **** , My name is ****** . I write to you to highlight the grave, deteriorating situation surrounding the Honeybee “Colony Collapse Disorder” [CCD], its relationship to the current autism epidemic and the need for urgent action to avoid a health and environmental catastrophe.

We have very little time to act; the British Beekeepers Association (BBKA) reports that if the crisis continues, honeybees will disappear completely from Britain by 2018, causing “calamitous” economic and environmental problems. The result, over the next ten years would be an estimated shortfall of 35% in food production. The rest of the developed world is not far behind, with the exception of Australia who has a very different policy on the use of antibiotics in animals and thus far has a thriving honeybee population.

Research into the aetiology of autism has shown that the CCD has almost certainly the same cause, namely deterioration in the health of our gut flora. As reviewed and explained by Paul Jaep in his web site “http://www.yeast-candida-infections-uk.co.uk/”, overuse of antibiotics has altered the balance of gut flora to favour yeast, triggering a cascade of events, the extreme manifestation of which, results in autism in humans and death in insects.

The politics of medicine and inertia to change is hindering recognition and research into this problem. If we hark back to the 1980’s, when the bacterium Helicobacter Pylori was eventually accepted as the cause of stomach ulcers and some cancers, it came after more than a decade of denial despite very good evidence that the bacterium was the cause. We cannot afford any such delay in confirming the aetiology of CCD/autism as our very civilisation is at stake.

We need urgent research into this hypothesis that autism and CCD are as a result of fungal infections in the gut. It would take very little work to confirm this, and considering the very serious situation I ask for your co-operation in bringing this about. We need to approach bio medical teams from selected universities to carry out animal/human studies, monitoring the effects of administering antibiotics, We need to know the amount of yeast generated, gut flora disruption, any Immune dysfunction, the ability or not normal flora has to re-establish .We need to know by molecular amplification [PCR testing] the presence of pathogens that do not culture. We need to be aware of the presence outside of the gut of bacteria that have the ability to avoid /manipulate the Immune system ,[see normal flora in web site] Is this a hitherto unknown method of disease progression? We need a comparison on captive bees with antibiotic contaminated soils and normal soils , how much antibiotic is taken up by plants .how much is transferred to the bee ..how disruptive is that to their immune system etc, ect: I’m sure given the principles involved academia can find many more relevant studies.

Alternative ending to journalists /editors specialising in environmental issues.

It’s clear that public opinion must be harnessed to stimulate debate. I along with most people who have read your articles appreciate your stance on environmental/health issues hence this letter. Blow the whistle Mr/Ms ***** because if you or someone like you doesn’t we’ve lost the war for sure. We need to approach bio medical teams from selected universities to carry out animal/human studies, monitoring the effects of administering antibiotics, We need to know the amount of yeast generated, gut flora disruption, any Immune dysfunction, the ability or not normal flora has to re-establish .We need to know by molecular amplification [PCR testing] the presence of pathogens that do not culture. We need to be aware of the presence outside of the gut of bacteria that have the ability to avoid /manipulate the Immune system ,[see normal flora in web site] Is this a hitherto unknown method of disease progression? I’m sure given the principles involved academia can find many more relevant studies.

The point is it would take very little work to confirm the hypothesis, and considering the very serious situation I ask for your co-operation in bringing this about.

I look forward to your reply

Regards