Inflammation
It is also a factor in constipation a condition that is common to autism.
Two remarkable men have worked out the role of inflammation in chronic infection, firstly Dr Trevor Marshall a Chronic Fatigue victim himself concluded that many of his own debilitating symptoms stemmed from a runaway inflammatory response and he worked out that this response was being fuelled by the pathogens. Completely independently of Dr Marshall and about the same time Gary Robert Smith here in the UK came to the same conclusions .Gary also analysed the molecular drivers of inflammation in the progression of cancer.
Gary Robert Smith's paper; Cancer, inflammation and the AT1 and AT2 receptors
Presentations of the original paper together with a further draft paper to leading oncologists here in the UK have been very well received; and they are supportive of clinical trials being set up. Limited empirical treatment in cancer in Japan shows great promise for the hypothesis.
Described as the wound that never heals, successful cancers (solid tumours) generate a wound-like environment on their boundary caused the physical and chemical stresses associated with their unrestrained growth. These tumour driven wound signals cause the destruction and remodelling of surrounding tissue, growth of new blood vessels to feed the growth of the tumour and incidentally also cause immune suppression by calling on lymphocytes to participate in the process. This could be compared to a ‘All hands on deck’ command, which diverts the attention of the cells from their day job of providing immunity to invaders to instead helping in response to the supposed emergency of a serious wound.
'Autoimmune' diseases and chronic inflammation associated with infection, in the opinion of the author, are also wounds that do not heal, but in these cases it is an infecting agent that utilises the wound response in order to divert the attention of the immune system.
Although inflammation can elicit a wound response alone things are complicated when the infectious agent is a stealth pathogen. In the absence of a presenting antigen [foreign body] the immune system reacts to the toxins and damage the pathogen creates. This reinforces the wound response, victims of stealth infections often become hyper-allergenic as the immune system becomes switched on permanently in response to tissue damage and toxins produced by the stealth pathogens
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